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Table 3 The lambdas of the three different approaches, averaged in case of multiple values. Full and detailed table with all values can be found in Supplementary material

From: Gene-based burden scores identify rare variant associations for 28 blood biomarkers

Biomarker

GenRisk

Genebass Burden Average

Genebass SKATO Average

AstraZeneca PheWAS Average

Alanine aminotransferase

1.016

1.139 ± 0.081

1.1967 ± 0.278

1.046 ± 0.016

Albumin

1.069

1.136 ± 0.132

1.231 ± 0.243

1.050 ± 0.018

Alkaline phosphatase

1.078

1.322 ± 0.259

1.739 ± 1.130

1.084 ± 0.023

Apolipoprotein A

1.068

1.207 ± 0.170

1.340 ± 0.317

1.070 ± 0.020

Apolipoprotein B

1.105

1.149 ± 0.094

1.247 ± 0.289

1.053 ± 0.018

Aspartate aminotransferase

0.951

1.174 ± 0.104

1.253 ± 0.285

1.064 ± 0.027

Calcium

1.063

1.099 ± 0.045

1.162 ± 0.140

1.053 ± 0.020

Cholesterol

1.085

1.158 ± 0.117

1.199 ± 0.266

1.050 ± 0.014

C-reactive protein

0.995

1.228 ± 0.178

1.505 ± 0.786

1.082 ± 0.0201

Creatinine

0.861

1.201 ± 0.158

1.328 ± 0.418

1.097 ± 0.027

Cystatin C

0.995

1.221 ± 0.173

1.376 ± 0.371

1.093 ± 0.030

Direct bilirubin

0.993

1.168 ± 0.146

1.411 ± 0.613

1.036 ± 0.001

Gamma glutamyltransferase

0.965

1.207 ± 0.078

1.384 ± 0.289

1.065 ± 0.030

Gluscose

0.998

1.081 ± 0.081

1.082 ± 0.111

1.019 ± 0.013

Glycated haemoglobin HbA1c

1.018

1.224 ± 0.125

1.391 ± 0.387

1.090 ± 0.026

HDL Cholesterol

1.076

1.231 ± 0.175

1.417 ± 0.474

1.075 ± 0.026

IGF1

1.084

1.212 ± 0.145

1.352 ± 0.396

1.096 ± 0.019

LDL direct

1.092

1.132 ± 0.119

1.179 ± 0.245

1.039 ± 0.016

Lipoprotein A

0.992

1.156 ± 0.152

1.354 ± 0.534

1.020 ± 0.008

Phosphate

1.065

1.041 ± 0.028

0.976 ± 0.060

1.054 ± 0.020

SHBG

1.07

1.194 ± 0.076

1.353 ± 0.336

1.065 ± 0.025

Testosterone

1.005

1.088 ± 0.105

1.072 ± 0.205

1.016 ± 0.014

Total bilirubin

1.028

1.264 ± 0.193

1.648 ± 0.911

1.030 ± 0.013

Total protein

1.059

1.194 ± 0.183

1.286 ± 0.323

1.078 ± 0.021

Triglycerides

1.066

1.197 ± 0.187

1.279 ± 0.362

1.071 ± 0.011

Urate

1.076

1.227 ± 0.054

1.429 ± 0.335

1.058 ± 0.018

Urea

1.036

1.116 ± 0.091

1.157 ± 0.226

1.049 ± 0.012

Vitamin D

1.034

1.089 ± 0.016

1.133 ± 0.135

1.049 ± 0.019